The shiny, mottled, black- or grey-toned fruits, often referred to as "seeds," are used in making the extract. Leaves have shiny, green upper surfaces and … Further investigation is warranted.Wang 2018 Silibinin inhibited HIV-1 replication in vitro.McClure 2012, In ovariectomized rats, treatment for 12 weeks with silymarin prevented bone loss, either through increasing formation via an effect on calcium, phosphorus, osteocalcin, and parathyroid hormone, or through direct action with estrogen receptor-beta.El-Shitany 2010 In another study of ovariectomized mice, silibinin or milk thistle extract 10 mg/kg/day administered for 8 weeks improved femoral bone mineral density and inhibited femoral bone loss caused by estrogen deficiency.Kim 2013, Silibinin may also induce autophagy, an evolving process of lysosomal proteolysis, which is vital for healthy organisms.Pallauf 2013, In vitro experiments and limited animal studies investigated the potential of silymarin and silibinin in a variety of cancer cell lines, including bladder, breast, cervical, colorectal, hepatocellular, gastric, lung, oral, ovarian, renal, and prostate. Milk thistle is a genus of two species of thistles in the daisy family. albiflorum Eig Silybum marianum var. Silybum marianum is sometimes known as Blessed Thistle. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Call us at 1 315 4971058. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. The more commonly used milk thistle seed extracts are not known to have estrogenic effects.Kidd 2005, Oral consumption of milk thistle (standardized to 70% to 80% silymarin) at 420 mg/day is considered safe for up to 41 months based on clinical trial data.Schandalik 1992 Acute oral toxicity of silymarin in rats, dogs, and monkeys has been estimated at dosages greater than 5 g/kg. Remove seed heads promptly after bloom to prevent self-seeding. Plants range from 2-6 ft. (0.6-1.8 m) in height, depending on soil moisture. Watch for slugs and snails. There are mixed data regarding milk thistle's ability to exert inhibitory or inductive activity on cytochrome P450 (CYP-450) 1A2, 2C19, 2D6, 2E1, and 3A4, as well as P-glycoprotein. Milk thistle flowers with seeds. Pricing Help Me Choose. is the most researched plant for the treatment of liver disease. Silybum marianum, commonly called blessed thistle or milk thistle, is a rosette-forming biennial that is native to the Mediterranean region (southern Europe, western Asia and northern Africa). The active ingredient, or liver-protecting compound in milk thistle is known as silymarin. Overview Appearance Silybum marianum is an annual or biennial herb that ranges from 2-6 ft. (0.6-1.8 m) in height. Disclaimer: ITIS taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. However, median ALT levels were not significantly different between groups. The flowers are reddish-purple and ridged with sharp spines. Silybum marianum and over 1000 other quality seeds for sale. A.Gray Silybum marianum var. It is common in the Western U.S. as a weed afflicting pastures, wastelands and irrigation banks. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The lower leaves are sessile (attached to the stem without petiole). Botanical name. For growth as an annual, sow seed indoors in March for planting outside at last spring frost date (flowers will appear in late summer followed by seed). This site makes an attempt to gather and share common names of the plants found in India. Application - has vernacular Full Name Holy thistle Name Id 055a7a8c-b7be-4921-80b9-2ed73189272c According To Nicol, E. R. 1997: Common Names of Plants in New Zealand. Cite this page: Tropicos.org. Family: Asteraceae Part used: Fruit/Seed Constituents: Flavolignans (silymarin complex), flavonoids, volatile oil, bitter principle, mucilage Actions: Cholagogue, hepatic, hepatoprotective & hepatorestorative, galactagogue, demulcent Medical uses: Research has shown that it promotes the regeneration of diseased liver cells and protects them … They have large, disc-shaped pink-to-purple, rarely white, solitary flower headsat the end of the stem. It is believed to have been introduced in cattle feed. FRE. General information about Silybum marianum (SLYMA) Euromediterranean (except north), Caucasus, Western Asia, Central Asia, Himalayas, India. The phyllaries under the flowers occur in many rows, with the outer ro… Basal leaves are 6-28 in. Arkansas. Liver-related mortality was significantly reduced by milk thistle when all trials were assessed (relative risk [RR], 0.5; 95% CI, 0.29 to 0.88) but not in high-quality trials (RR, 0.57; 95% CI, 0.28 to 1.19).Rambaldi 2007 In some trials, a reduction in serum transaminases was demonstrated but with no effect on liver histology or clinical progression.Ferenci 2008, Mayer 2005, Saller 2008 Symptoms related to biliary retention resolved faster in 1 subsequent trial, but with no effect on quality-of-life measures.El-Kamary 2009 One small, open-label study in viral hepatitis demonstrated a reduction in viral load with high-dose intravenous (IV) administration of silibinin.Ferenci 2008 However, orally administered silymarin did not produce differences in serum hepatitis C virus titers, ALT, or quality-of-life measurements compared with placebo, according to a meta-analysis of 5 randomized clinical trials (N=389) published through April 2014.Yang 2014 The Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial assessed the long-term use of silymarin in 1,049 patients with advanced fibrosis or cirrhosis after peginterferon and ribavirin therapy had failed. Milk production was enhanced with no change to its chemical composition.Di Pierro 2008, There is mixed data regarding milk thistle's ability to exert inhibitory or inductive activity on CYP1A2, 2C19, 2D6, 2E1, and 3A4, as well as P-glycoprotein. Silybum marianum. ›holy thistle ›lady's thistle ›milk thistle: Rank i: SPECIES: Lineage i Treatment was well tolerated with no adverse events reported.Ebrahimpour-Koujan 2018. The Garden wouldn't be the Garden without our Members, Donors and Volunteers. Losartan may be impacted depending on the CYP2C9 genotype. A.Gray Silybum marianum var. Mushrooms often kill by killing your liver. The origins of Silybum marianum lie in the region of Southern Europe, the Mediterranean and Northern Africa. Consumer information about the medication MILK THISTLE (Silybum marianum) - ORAL, includes side effects, drug interactions, recommended dosages, and storage information. Silybum marianum, also called milk thistle, is an annual or biannual plant belonging to the Asteraceae family. Family Name: Compositae. This species is an annual or biennial plant of the Asteraceae family. Mediterranean regions, Meadows, Borders of forests. Use of silymarin was associated with less fibrosis as measured by the Ishak fibrosis score, but this association was not noted for clinical outcome measures.Freedman 2011 The American Association for Study of Liver Disease (AASLD) practice guidelines for primary biliary cirrhosis (2009) and primary biliary cholangitis (2018) state that the addition of silymarin to ursodeoxycholic acid provided no additional benefit.Lindor 2009, Lindor 2019, A meta-analysis evaluated English and Chinese randomized placebo-controlled trials from 1966 to December 2011 to determine the safety and efficacy of silymarin as monotherapy and combination therapy for treatment of chronic hepatitis B.Wei 2013 Data from 12 trials (N=1,096) suggest silymarin is equivalent to antiviral or hepatoprotective drugs with regard to effects on serum transaminases, viral load, and hepatic fibrosis markers. Toxic effects of silymarin have not been noted clinically at a dosage of 1,200 mg/day; however, mild allergies have been reported with dosages greater than 1,500 mg/day. However, when silymarin was combined with these agents, serum indices and hepatic markers were reduced. Thats a bit hint as to what this plant does…..it protects the liver from damage. Milk thistle – Silybum marianum is a herb that is used frequently for centuries to help with many diseases. The HMPC conclusions only cover milkthistle fruit preparations that are obtained by drying and comminuting (reducing into tiny pieces) or powdering the fruit or putting the plant material in a solvent (acetone, ethanol, ethyl acetate or methanol) to dissolve compounds and form a liquid extract. Those receiving silibinin achieved a greater reduction in total bilirubin at day 28 compared with placebo.Greenlee 2007, NIH 2018, In a randomized, double-blind, placebo-controlled study, effects of silymarin 140 mg 3 times daily on radiation-induced oral mucositis were assessed in 27 patients with head and neck cancer. marianum Silybum pygmaeum Cass. (syn. Synonym. Milk thistle was a traditional treatment for mushroom poisoning. Scientific name: Carduus marianus (L.) Common name: Holy thistle, milk thistle, Our Lady's thistle: Hebrew name: גדילן מצוי: Arabic name: خرفيش جمال: Egypt: شوك الجمل "Shouk El-Gamal" Plant Family: Compositae / Asteraceae, מורכבים One source suggests daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the biliary system, while an extract containing 200 to 400 mg/day of silymarin is considered effective in various liver disorders. Scientific Name(s): Silybum marianum (L.) Gaertn.Common Name(s): Carduus marianus, Fructus cardui mariae, Fructus silybi mariae, Mariana mariana, Blessed milk thistle, Bull thistle, Chardon de Marie, Holy thistle, Lady's milk, Lady's thistle, Marian thistle, Mary thistle, Mild marian thistle, Milk thistle, Pternix, Shui fei ji, Silberdistil, Silibinin, Silybe, Silybon, Silybum, Silymarin, St. Mary's thistle, Thistle, Thistle of the Blessed Virgin, Wild artichoke. Pricing Help Me Choose. This product may be unsafe when used before surgery or other medical procedures. Scientific Name: Silybum marianum Common name: Variegated thistle Page 1 of 2 QUESTION COMMENTS REFERENCE RANKING Social 1. Additionally, varicocelized rats receiving silymarin had higher testosterone levels and a larger percentage of sperm with nuclear maturity compared with varicocelized rats not receiving treatment.Moshtaghion 2013, Milk thistle is considered safe in dosages of 420 mg/day orally in divided doses for up to 41 months.Milić 2013, Tamayo 2007 One source suggests daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the biliary system, while an extract containing 200 to 400 mg/day of silymarin is considered effective in various liver disorders.van Wyk 2004, A dose of 140 mg of silymarin 3 times daily has been suggested for hepatic cirrhosis.Stolf 2017, S. marianum leaf extract 600 mg/day (200 mg capsules 3 times daily) given for 8 weeks was as effective as fluoxetine in adults with obsessive-compulsive disorder in a small study.Sayyah 2010, A phase 1 clinical study in prostate cancer patients determined a phase 2 dosage recommendation of silibinin (as Siliphos) 13 g/day orally in 3 divided doses.Flaig 2007, Ramasamy 2008, A preparation consisting of 150 mL of boiling water poured over 3.5 g of crushed milk thistle seed, steeped for 10 to 15 minutes, and given 3 to 4 times daily 30 minutes before meals has been suggested for digestive disorders.Blumenthal 2003 Consumption of silymarin in the form of tea may not be effective, as silymarin is poorly soluble in water.Awang 2009. The common name, Milk Thistle, ... Silybum marianum (PLANTS Database, 12 November 2019). Leaves and stems exude a milky sap when cut, hence the common name of milk thistle. (Syn. Milk thistle has been used medicinally since the fourth century BC. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East. This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. Common name: Blessed milkthistle, Milk thistle, Marian thistle, Mary thistle, Saint Mary’s thistle, Mediterranean milk thistle, Variegated thistle Scientific Name: Silybum marianum. 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